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John F Boylan Selected Research

2,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamide

3/2015Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.
7/2012Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.
6/2011High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097.
1/2011The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.
10/2009Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

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John F Boylan Research Topics

Disease

11Neoplasms (Cancer)
01/2018 - 05/2003
2Breast Neoplasms (Breast Cancer)
01/2018 - 03/2004
2Triple Negative Breast Neoplasms
01/2018 - 11/2017
2Melanoma (Melanoma, Malignant)
01/2012 - 01/2011
2Acidosis
11/2005 - 01/2004
2Acute Lung Injury
11/2005 - 01/2004
2Lung Injury
11/2005 - 01/2004
1Body Weight (Weight, Body)
01/2019
1Glioma (Gliomas)
03/2015
1Ependymoma
03/2015
1Glioblastoma (Glioblastoma Multiforme)
03/2015
1Leukemia
02/2014
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2011
1Colonic Neoplasms (Colon Cancer)
08/2011
1Hypercapnia
11/2005
1Ischemia
11/2005
1Hypoxia (Hypoxemia)
05/2003

Drug/Important Bio-Agent (IBA)

5Amyloid Precursor Protein Secretases (beta-Secretase)IBA
03/2015 - 10/2009
52,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
03/2015 - 10/2009
4Phosphotransferases (Kinase)IBA
11/2017 - 05/2003
3Proteins (Proteins, Gene)FDA Link
11/2011 - 01/2004
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2012 - 08/2011
2EndotoxinsIBA
11/2005 - 01/2004
1pyrimidineIBA
01/2019
1Pharmaceutical PreparationsIBA
01/2018
1Phenobarbital (Luminal)FDA Link
01/2018
1CDC2 Protein Kinase (Protein p34cdc2)IBA
11/2017
1Temozolomide (Temodar)FDA LinkGeneric
03/2015
1DNA (Deoxyribonucleic Acid)IBA
03/2015
1Etoposide (VP 16)FDA LinkGeneric
03/2015
1Small Interfering RNA (siRNA)IBA
02/2014
1SuspensionsIBA
02/2014
1Lipid NanoparticlesIBA
02/2014
1Proto-Oncogene Proteins B-rafIBA
01/2012
1GemcitabineFDA Link
11/2011
1Caspase 3 (Caspase-3)IBA
11/2011
1Cisplatin (Platino)FDA LinkGeneric
11/2011
1Serine (L-Serine)FDA Link
11/2011
1Interleukin-6 (Interleukin 6)IBA
06/2011
1Interleukin-8 (Interleukin 8)IBA
06/2011
1Ceftriaxone (Ceftriaxon)FDA LinkGeneric
11/2005
1Anti-Bacterial Agents (Antibiotics)IBA
11/2005
1NIMA-Related KinasesIBA
03/2004
1Protein Kinases (Protein Kinase)IBA
03/2004
1Amino AcidsFDA Link
03/2004
1NitrogenIBA
01/2004
1Peroxynitrous Acid (Peroxynitrite)IBA
01/2004
13-nitrotyrosineIBA
01/2004
1OxidesIBA
01/2004

Therapy/Procedure

2Therapeutics
06/2011 - 11/2005
1Heterologous Transplantation (Xenotransplantation)
01/2011